The extracts of seeds of Prosopis cineraria (Family Leguminosae) were investigated for anti-inflammatory activity in rats using glass rod granuloma method. The seeds of Prosopis cineraria were collected from the forest area of Gulbarga district., Karnataka. The dried powdered seeds (1000 gm) were extracted in a soxhlet apparatus by using different solvents, Rats weighing 130 gm were taken for the experiment, and oral toxicity testing was performed as per OECD guidelines. All data were analyzed with Dunnet’s test. The etahnolic and aqueous extracts of the seeds of Prosopis cineraria showed significant anti-inflammatory activity at a dose of 100 mg/kg body weight, when compared with control and standard drug indomethacin.
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